After a group of telemarketers get fired by their penny-pinching boss, they take revenge by stealing the company's list of clients to start up their own firm. In the heat of celebration and a few drinks in, they lose the phone which holds the only copy of their future customers. While tracking the lost device on Halloween night, co-workers Amber and Will find themselves trapped in a demented drug addict's house of horrors.

Jack Sadelstein is a successful advertising executive in Los Angeles with a beautiful wife and kids, who dreads one event each year: the Thanksgiving visit of his fraternal twin sister Jill. Jill's neediness and passive-aggressiveness is maddening to Jack, turning his normally tranquil life upside down.